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OnPremisesSmtpClientSubmissionMonitor Reporting as Unhealthy on CAS servers

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We recently patched our servers to CU9. The FrontendTransport\OnPremisesSmtpClientSubmissionMonitor now reports it is Unhealthy. In the monitoring logs the following is found:

The client submission probe failed 3 times over 15 minutes.
Server 127.0.0.1 on port 587 did not respond with expected response (OK). The actual response was: 550 5.7.1 Client does not have permissions to send as this sender
.
Probe Exception: 'System.Exception: Server 127.0.0.1 on port 587 did not respond with expected response (OK). The actual response was: 550 5.7.1 Client does not have permissions to send as this sender
.
   at Microsoft.Forefront.Monitoring.ActiveMonitoring.Smtp.Probes.SmtpConnectionProbe.AssertExpectedResponse(SmtpExpectedResponse expectedResponse)
   at Microsoft.Forefront.Monitoring.ActiveMonitoring.Smtp.Probes.SmtpConnectionProbe.TestConnection()
   at Microsoft.Forefront.Monitoring.ActiveMonitoring.Smtp.Probes.SmtpConnectionProbe.DoWork(CancellationToken cancellationToken)
   at Microsoft.Office.Datacenter.WorkerTaskFramework.WorkItem.Execute(CancellationToken joinedToken)
   at Microsoft.Office.Datacenter.WorkerTaskFramework.WorkItem.<>c__DisplayClass2.<StartExecuting>b__0()
   at System.Threading.Tasks.Task.Execute()'
Failure Context: 'Server 127.0.0.1 on port 587 did not respond with expected response (OK). The actual response was: 550 5.7.1 Client does not have permissions to send as this sender
.'
Execution Context: ''
Probe Result Name: 'OnPremisesSmtpClientSubmission'
Probe Result Type: 'Failed'
Monitor Total Value: '3'
Monitor Total Sample Count: '3'
Monitor Total Failed Count: '0'
Monitor Poisoned Count: '0'
Monitor First Alert Observed Time: 

How do we resolve this issue?


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